This list was compiled by Thomas Nelson from several data sources. Unlike every other bestsellers list, this one combines sales through the three major retail book channels: (1) general market bookstores, (2) mass market outlets, and (3) Christian specialty bookstores. Rows highlighted in brown are Christian titles.
| # | Title | Author | Publisher | ISBN | FM | Retail | Release |
| 1 | A Million Little Pieces | James Frey | Random House | 0307276902 | TP | $14.95 | 09/05 |
| 2 | The Holy Bible (NKJV) | N/A | Thomas Nelson | 0718010868 | TP | $2.99 | 02/05 |
| 3 | Marley & Me | John Grogan | HarperCollins | 0060817089 | HC | $21.95 | 10/05 |
| 4 | The Da Vinci Code | Dan Brown | Random House | 1400079179 | MM | $7.99 | 03/06 |
| 5 | Night | Elie Wiesel | Farrar Straus Giroux | 0374500010 | TP | $9.00 | 06/06 |
| 6 | A Broker | John Grisham | Random House | 0440241588 | MM | $7.99 | 11/06 |
| 7 | The Memory Keeper's Daughter | Kim Edwards | Penguin | 0143037145 | TP | $14.00 | 05/06 |
| 8 | The Kite Runner | Kha Hosseini | Penguin | 1594480001 | TP | $14.00 | 04/04 |
| 9 | Red Lily | Nora Roberts | Penguin | 0515139408 | MM | $7.99 | 11/05 |
| 10 | Rachael Ray 365 | Rachael Ray | Random House | 1400082544 | TP | $19.95 | 11/05 |
| 11 | For One More Day | Mitch Albom | Hyperion | 1401303277 | HC | $21.95 | 09/06 |
| 12 | The Purpose-Driven Life | Rick Warren | Zondervan | 0310205719 | HC | $19.99 | 10/02 |
| 13 | The Da Vinci Code | Dan Brown | Random House | 0385504209 | HC | $24.95 | 03/03 |
| 14 | Freakonomics | Steven D. Levitt & Stephen J. Dubner | HarperCollins | 0061234001 | HC | $27.95 | 04/06 |
| 15 | The World Is Flat | Thomas L. Friedman | Farrar Straus Giroux | 0374292884 | HC | $27.50 | 04/05 |
| 16 | Memoirs of a Geisha | Arthur Golden | Random House | 0307275167 | TP | $14.95 | 11/05 |
| 17 | Cell | Stephen King | Simon & Schuster | 0743292332 | HC | $26.95 | 01/06 |
| 18 | Wicked | Gregory Maguire | HarperCollins | 0060987103 | TP | $16.00 | 12/00 |
| 19 | Your Best Life Now | Joel Osteen | Hachette | 0446532754 | TC | $21.99 | 10/04 |
| 20 | The End | Lemony Snicket | HarperCollins | 0064410161 | TC | $12.99 | 10/06 |
| 21 | Sudoku Easy Presented | Will Shortz | St. Martin’s Press | 0312355025 | TP | $6.95 | 08/05 |
| 22 | Honeymoon | James Patterson | Hachette | 0446696269 | TP | $13.95 | 01/06 |
| 23 | Angels & Demons | Dan Brown | Simon & Schuster | 1416524797 | MM | $9.99 | 03/06 |
| 24 | The Innocent Man | John Grisham | Random House | 0385517238 | HC | $28.95 | 10/06 |
| 25 | The Da Vinci Code | Dan Brown | Random House | 0307277674 | TP | $14.95 | 03/06 |
| 26 | The Chronicles of Narnia | C. S. Lewis | Zondervan | 0066238501 | TP | $21.99 | 10/01 |
| 27 | The Five Love Languages | Gary Chapman | Moody | 1881273156 | TP | $13.99 | 10/92 |
| 28 | Captivating | John and Stasi Eldredge | Thomas Nelson | 0785264698 | HC | $22.99 | 04/05 |
| 29 | In Cold Blood | Truman Capote | Random House | 0679745580 | TP | $14.00 | 02/94 |
| 30 | Teacher Man | Frank McCourt | Simon & Schuster | 0743243773 | HC | $26.00 | 11/05 |
| 31 | Cesar's Way | Cesar Millan | Random House | 0307337332 | HC | $24.95 | 04/06 |
| 32 | Mary, Mary | James Patterson | Hachette | 031615976X | HC | $27.95 | 11/05 |
| 33 | The Glass Castle | Jeanne Walls | Simon & Schuster | 074324754X | TP | $14.00 | 01/06 |
| 34 | Beach Road | James Patterson | Hachette | 0316159786 | HC | $27.95 | 05/06 |
| 35 | My Sister's Keeper | jodi Picoult | Simon & Schuster | 0743454537 | TP | $14.00 | 02/05 |
| 36 | Memoirs of a Geisha | Arthur Golden | Random House | 1400096898 | MM | $7.99 | 11/05 |
| 37 | State of Denial | Bob Woodward | Simon & Schuster | 0743272234 | HC | $30.00 | 09/06 |
| 38 | Team of Rivals | Doris Kearns Goodwin | Simon & Schuster | 0684824906 | HC | $35.00 | 10/05 |
| 39 | Our Endangered Values | Jimmy Carter | Simon & Schuster | 0743284577 | HC | $25.00 | 10/05 |
| 40 | YOU: The Owner's Manual | Michael F. Roizen & Mehmet Oz | HarperCollins | 0060765313 | HC | $24.95 | 05/05 |
| 41 | Vanishing Acts | Jodi Picoult | Simon & Schuster | 0743454553 | TP | $14.00 | 11.05 |
| 42 | The Year of Magical Thinking | Joan Didion | Random House | 140004314X | HC | $23.95 | 10/05 |
| 43 | Jerusalem Countdown | John Hagee | Frontline | 1591858933 | TP | $14.99 | 06/06 |
| 44 | The Tipping Point | Malcolm Gladwell | Hachette | 0316346624 | TP | $14.95 | 01/02 |
| 45 | The Mermaid Chair | Sue Monk Kidd | Penguin | 0143036696 | TP | $14.00 | 03/06 |
| 46 | The Secret Life of Bees | Sue Monk Kidd | Penguin | 0142001740 | TP | $14.00 | 01/03 |
| 47 | The Chronicles of Narnia | C. S. Lewis | HarperCollins | 0060765453 | TP | $21.99 | 10/05 |
| 48 | What to Expect When You're Expecting | Heidi Murkoff, Arlene Eisenberg, & Sandee Hathaway | Workman Press | 0761121323 | TP | $13.95 | 01/02 |
| 49 | You: On a Diet | Michael F. Roizen & Mehmet Oz | Simon & Schuster | 0743292545 | HC | $25.00 | 10/06 |
| 50 | S is for Silence | Sue Grafton | Penguin | 0399152970 | HC | $26.95 | 12/05 |
| 51 | Twelve Sharp | Janet Evanovich | St. Martin’s Press | 0312349483 | HC | $26.95 | 06/06 |
| 52 | The World Is Flat (Updated and Expanded) | Thomas L. Friedman | Farrar Straus Giroux | 0374292795 | TC | $30.00 | 04/06 |
| 53 | 4th of July | James Patterson | Hachette | 0446613363 | MM | $9.99 | 06/06 |
| 54 | Running with Scissors | Augusten Burroughs | St. Martin’s Press | 031242227X | TP | $14.00 | 06/03 |
| 55 | Harry Potter and the Half-Blood Prince | J. K. Rowling | Scholastic | 0439784549 | HC | $29.99 | 07/05 |
| 56 | Rich Dad, Poor Dad | Robert T. Kiyosaki | Hachette | 0446677450 | TP | $16.95 | 01/98 |
| 57 | Eldest | Christopher Paolini | Random House | 037582670X | TC | $21.00 | 08/05 |
| 58 | Love Smart | Phil McGraw | Simon & Schuster | 0743272099 | HC | $26.00 | 12/05 |
| 59 | Su Doku for Dummies | Andrew Heron, Edmund James | Wiley | 0470018925 | TP | $9.99 | 08/05 |
| 60 | 1776 | David McCullough | Simon & Schuster | 0743226712 | HC | $32.00 | 05/05 |
| 61 | 90 Minutes in Heaven | Don Piper | Baker | 0800759494 | TP | $12.99 | 09/04 |
| 62 | Good to Great | Jim Collins | HarperCollins | 0066620996 | TC | $27.50 | 10/01 |
| 63 | Pocket Sudoku, Vol. 1 | Will Shortz | St. Martin’s Press | 031296708X | MM | $4.99 | 11/05 |
| 64 | Angels & Demons | Dan Brown | Simon & Schuster | 0671027360 | MM | $7.99 | 07/01 |
| 65 | The Penultimate Peril | Lemony Snicket | HarperCollins | 0064410153 | TC | $12.99 | 10/05 |
| 66 | Goodnight Moon | Margaret Wise Brown | HarperCollins | 0694003611 | BD | $7.99 | 09/91 |
| 67 | At First Sight | Nicholas Sparks | Hachette | 0446532428 | HC | $24.95 | 10/05 |
| 68 | Natural Cures ÒTheyÓ Don’t Want You To Know About | Kevin Trudeau | Alliance Publishing | 0975599518 | TC | $29.95 | 01/04 |
| 69 | The Curious Incident of the Dog in the Night-Time | Mark Haddon | Random House | 1400032717 | TP | $12.95 | 05/04 |
| 70 | Prep | Curtis Sittenfeld | Random House | 081297235X | TP | $13.95 | 11/05 |
| 71 | The Five People You Meet in Heaven | Mitch Albom | Hyperion | 1401308589 | TP | $12.00 | 03/06 |
| 72 | Lifeguard | James Patterson | Hachette | 044661761X | MM | $9.99 | 07/06 |
| 73 | The Closers | Michael Connelly | Hachette | 0446616443 | MM | $7.99 | 02/06 |
| 74 | Judge & Jury | James Patterson, Andrew Gross | Hachette | 0316013935 | TC | $27.99 | 07/06 |
| 75 | State of Fear | Michael Crichton | HarperCollins | 0061015733 | MM | $7.99 | 10/05 |
| 76 | To Kill a Mockingbird | Harper Lee | Hachette | 0446310786 | MM | $6.99 | 11/88 |
| 77 | Eragon | Christopher Paolini | Random House | 0375826696 | TP | $10.95 | 04/05 |
| 78 | Why Do Men Have Nipples? | Mark Leyner, Billy Goldberg | Random House | 1400082315 | TP | $13.95 | 07/05 |
| 79 | The Devil in the White City | Erik Larson | Random House | 0375725601 | TP | $14.95 | 02/04 |
| 80 | I Feel Bad About My Neck | Nora Ephron | Random House | 0307264556 | TC | $19.95 | 08/06 |
| 81 | The 5th Horseman | James Patterson | Hachette | 0316159778 | HC | $27.95 | 02/06 |
| 82 | The South Beach Diet | Arthur Agatston | St. Martin’s Press | 031231521X | TP | $14.95 | 04/05 |
| 83 | Battlefield of the Mind | Joyce Meyer | Hachette | 0446691097 | TP | $14.99 | 10/02 |
| 84 | Blink | Malcolm Gladwell | Hachette | 0316172324 | HC | $25.95 | 01/05 |
| 85 | Fiesta Bible Book | Alaskan Moose (Illustrator) | Group Publishing | 0764429620 | TP | $2.99 | 06/06 |
| 86 | Jim Cramer’s Real Money | James J. Cramer | Simon & Schuster | 0743224892 | HC | $36.00 | 04/05 |
| 87 | Digital Fortress | Dan Brown | St. Martin’s Press | 0312995423 | MM | $7.99 | 01/04 |
| 88 | Gilead | Marilynne Robinson | St. Martin’s Press | 031242440X | TP | $14.00 | 01/06 |
| 89 | Snow Flower and the Secret Fan | Lisa See | Random House | 0812968069 | TP | $13.95 | 02/06 |
| 90 | Cure for the Common Life | Max Lucado | Thomas Nelson | 0849900085 | HC | $22.99 | 01/06 |
| 91 | Mere Christianity | C. S. Lewis | HarperCollins | 0060652926 | TP | $11.95 | 02/01 |
| 92 | The Devil Wears Prada | Lauren Weisberger | Random House | 0307275558 | MM | $7.99 | 05/06 |
| 93 | The Audacity of Hope | Barack Obama | Random House | 0307237699 | HC | $25.00 | 10/06 |
| 94 | Morrigan’s Cross | Nora Roberts | Penguin | 0515141658 | MM | $7.99 | 08/06 |
| 95 | Culture Warrior | Bill O’Reilly | Random House | 0767920929 | HC | $26.00 | 09/06 |
| 96 | Wisdom of Our Fathers | Tim Russert | Random House | 1400064805 | HC | $22.95 | 05/06 |
| 97 | Pocket Sudoku, Vol. 2 | Will Shortz | St. Martin’s Press | 031296711X | MM | $4.99 | 11/05 |
| 98 | Blue Like Jazz | Donald Miller | Thomas Nelson | 0785263705 | TP | $13.99 | 06/03 |
| 99 | Deception Point | Dan Brown | Simon & Schuster | 1416524800 | MM | $9.99 | 04/06 |
| 100 | My Friend Leonard | James Frey | Penguin | 1573223158 | HC | $24.95 | 07/05 |